Cellosaurus logo
expasy logo

Cellosaurus HCC4006 BIR (CVCL_E4DJ)

[Text][XML][JSON]
Cell line name HCC4006 BIR
Synonyms HCC4006BIR
Accession CVCL_E4DJ
Resource Identification Initiative To cite this cell line use: HCC4006 BIR (RRID:CVCL_E4DJ)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_232716; (20R)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15H,17H-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6H)-one (BI-4020).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Epithelial cell; CL=CL_0000066.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1269 (HCC4006)
Sex of cell Male
Age at sampling >50Y
Category Cancer cell line
Publications

PubMed=39061985; DOI=10.3390/biomedicines12071412; PMCID=PMC11273927
Shota Fukuda, Kenichi Suda, Akira Hamada, Hana Oiki, Shuta Ohara, Masaoki Ito, Junichi Soh, Tetsuya Mitsudomi, Yasuhiro Tsutani;
Potential utility of a 4th-generation EGFR-TKI and exploration of resistance mechanisms -- an in vitro study.
Biomedicines 12:1412.1-1412.13(2024)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2