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Cellosaurus K-562 KL/4 (CVCL_E4AI)

[Text version]
Cell line name K-562 KL/4
Synonyms KL/4
Accession CVCL_E4AI
Resource Identification Initiative To cite this cell line use: K-562 KL/4 (RRID:CVCL_E4AI)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6148; ITGAL.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6155; ITGB2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=7535698; DOI=10.1002/eji.1830250302
Susan Ortlepp, Paul E. Stephens, Nancy Hogg, Carl Gustav Figdor, Martyn K. Robinson;
Antibodies that activate beta 2 integrins can generate different ligand binding states.
Eur. J. Immunol. 25:637-643(1995)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2