Cellosaurus logo
expasy logo

Cellosaurus BJ SiPS-D TH-TdTomato ATP10B KO clone #1 (CVCL_E3SX)

[Text version]
Cell line name BJ SiPS-D TH-TdTomato ATP10B KO clone #1
Synonyms TH-TdTomato BJ SiPS ATP10B KO clone #1
Accession CVCL_E3SX
Resource Identification Initiative To cite this cell line use: BJ SiPS-D TH-TdTomato ATP10B KO clone #1 (RRID:CVCL_E3SX)
Comments Population: Caucasian.
Characteristics: Fluorescent (tdTomato) reporter cell line for TH expression. Using CRISPR/Cas9 a P2A-tdTomato construct was introduced in the C-terminal end of TH (from parent cell line).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:13543; ATP10B.
Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Derived from site: In situ; Foreskin, skin; UBERON=UBERON_0001471.
Cell type: Fibroblast of foreskin; CL=CL_1001608.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C8FN (BJ SiPS-D TH-TdTomato)
Sex of cell Male
Age at sampling <1M
Category Induced pluripotent stem cell
Publications

DOI=10.1101/2024.07.09.602700
Maria Sanchiz-Calvo, Elena Coccia, Christopher Cawthorne, Gustavo Morrone Parfitt, Koen Van Laere, Teresa Torre-Muruzabal, Diego Cabezudo, George Tsafaras, Ana Catarina Carapinha Cascalho, Chris Van den Haute, Peter Vangheluwe ...Show all 14 authors... , Joel W. Blanchard, Eduard Bentea, Veerle Baekelandt; Show fewer authors
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits.
bioRxiv 2024:07.09.602700-07.09.602700(2024)

Entry history
Entry creation19-Dec-2024
Last entry update19-Dec-2024
Version number1