Cellosaurus cell line BIHi005-A-39 (CVCL

Cellosaurus BIHi005-A-39 (CVCL_E3RN)

Cross-references
Cell line name	BIHi005-A-39
Synonyms	hiPSC M368A; M368A hiPSC; BIHi005-A-M2 (ATG>GCT) M2 Cholinergic Receptor
Accession	CVCL_E3RN
Resource Identification Initiative	To cite this cell line use: BIHi005-A-39 (RRID:CVCL_E3RN)
Comments	From: Berlin Institute of Health; Berlin; Germany. Population: Asian. Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067. Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations	Mutation; HGNC; HGNC:1951; CHRM2; Simple_edited; p.Met368Ala (c.1102_1104ATG>GCT); Zygosity=Homozygous; Note=By CRISPR/Cas9 (PubMed=38683874).
Disease	Alzheimer's disease (NCIt: C2866)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_IT56 (BIHi005-A)
Sex of cell	Male
Age at sampling	25-29Y
Category	Induced pluripotent stem cell
Publications	PubMed=38683874; DOI=10.1371/journal.pbio.3002582; PMCID=PMC11093360 Irene Fasciani, Francesco Petragnano, Zi-Ming Wang, Ruairidh Edwards, Narasimha Swamy Telugu, Ilaria Pietrantoni, Ulrike Zabel, Henrik Zauber, Marlies Grieben, Maria-Eirini Terzenidou, Jacopo Di Gregorio ...Show all 32 authors... , Cristina Pellegrini, Silvano Santini Jr., Anna Rita Taddei, Barbel Pohl, Stefano Aringhieri, Marco Carli, Gabriella Aloisi, Francesco Marampon, Eve Charlesworth, Alexandra Roman, Sebastian Diecke, Vincenzo Flati, Franco Giorgi, Fernanda Amicarelli, Andrew B. Tobin, Marco Scarselli, Kostas Tokatlidis, Mario Rossi, Martin Johannes Lohse, Paolo Annibale, Roberto Maggio; Show fewer authors The C-terminus of the prototypical M2 muscarinic receptor localizes to the mitochondria and regulates cell respiration under stress conditions. PLoS Biol. 22:e3002582.1-e3002582.36(2024)
Cell line databases/resources	hPSCreg; BIHi005-A-39
Entry history
Entry creation	19-Dec-2024
Last entry update	19-Dec-2024
Version number	1