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Cellosaurus HS5-CD40L(LOW)-IL4 (CVCL_E3RJ)

[Text version]
Cell line name HS5-CD40L(LOW)-IL4
Synonyms HS5-CD40LLOW-IL4
Accession CVCL_E3RJ
Resource Identification Initiative To cite this cell line use: HS5-CD40L(LOW)-IL4 (RRID:CVCL_E3RJ)
Comments Population: Caucasian.
Characteristics: Expresses low level of CD40LG (PubMed=38877102).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11935; CD40LG.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6014; IL4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Bone marrow, stroma; UBERON=UBERON_0007195.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3RG (HS5-IL4)
Children:
CVCL_E3RI (HS5-CD40L-IL4)
Sex of cell Male
Age at sampling 30Y
Category Transformed cell line
Publications

PubMed=38877102; DOI=10.1038/s41375-024-02284-w; PMCID=PMC11286525
Eva Hoferkova, Vaclav Seda, Sona Kadakova, Jan Verner, Tomas Loja, Kvetoslava Matulova, Hana Skuhrova Francova, Eva Ondrouskova, Daniel Filip, Nicolas Blavet, Miroslav Boudny ...Show all 29 authors... , Gabriela Mladonicka Pavlasova, Josef Vecera, Laura Ondrisova, Petra Pavelkova, Krystof Hlavac, Lenka Kostalova, Androniki Michaelou, Sarka Pospisilova, Jana Dorazilova, Vaclav Chochola, Josef Jaros, Michael Doubek, Marie Jarosova, Ales Hampl, Lucy Vojtova, Leos Kren, Jiri Mayer, Marek Mraz; Show fewer authors
Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs.
Leukemia 38:1699-1711(2024)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3