Cellosaurus cell line HyCyte NCI-H2228-Luc (CVCL

Cross-references
Cell line name	HyCyte NCI-H2228-Luc
Synonyms	Luciferase Reporter NCI-H2228 Cell Line
Accession	CVCL_E3I6
Resource Identification Initiative	To cite this cell line use: HyCyte NCI-H2228-Luc (RRID:CVCL_E3I6)
Comments	Population: Caucasian. Doubling time: 24-48 hours (Hysigen=TCH-C278L). Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations	Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK; Note=E6A20 v3 fusion (from parent cell line). Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:9655; PTPN3; Name(s)=ALK-PTPN3 (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Homozygous (from parent cell line).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1543 (NCI-H2228)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; TCH-C278L
Entry history
Entry creation	19-Dec-2024
Last entry update	14-Aug-2025
Version number	3