Cellosaurus cell line HyCyte NCI-H157-Luc (CVCL

Cross-references
Cell line name	HyCyte NCI-H157-Luc
Synonyms	Luciferase Reporter NCI-H157 Cell Line
Accession	CVCL_E3I3
Resource Identification Initiative	To cite this cell line use: HyCyte NCI-H157-Luc (RRID:CVCL_E3I3)
Comments	Problematic cell line: Contaminated. Parent cell line (NCI-H157) has been shown to be identical to NCI-H1264. Doubling time: 24-48 hours (Hysigen=TCH-C431L). Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Sequence variations	Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu35Phefs*8 (c.102_103insT) (c.103_104insT); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Heterozygous (from parent cell line).
Disease	Lung squamous cell carcinoma (NCIt: C3493)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0463 (NCI-H157)
Sex of cell	Male
Age at sampling	59Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; TCH-C431L
Entry history
Entry creation	19-Dec-2024
Last entry update	14-Aug-2025
Version number	2