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Cellosaurus 12D7-NEO (CVCL_E3GC)

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Cell line name 12D7-NEO
Accession CVCL_E3GC
Resource Identification Initiative To cite this cell line use: 12D7-NEO (RRID:CVCL_E3GC)
Comments Population: Caucasian.
Characteristics: Control cell line for 12D7-MDR1 (Cellosaurus=CVCL_A9MA), 12D7-MDR1-IRES-DHFR (Cellosaurus=CVCL_E3GD) and 12D7-MDR1mt-IRES-DHFR (Cellosaurus=CVCL_E3GE) (PubMed=10698967).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_W647 (12D7)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=10698967; DOI=10.1096/fasebj.14.3.516
Caroline G.L. Lee, Murali Ramachandra, Kuan-Teh Jeang, Malcolm A. Martin, Ira Pastan, Michael Marc Gottesman;
Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter.
FASEB J. 14:516-522(2000)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2