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Cellosaurus HCI-EC-23 (CVCL_E3GB)

[Text version]
Cell line name HCI-EC-23
Synonyms Huntsman Cancer Institute-Endometrial cancer-23
Accession CVCL_E3GB
Resource Identification Initiative To cite this cell line use: HCI-EC-23 (RRID:CVCL_E3GB)
Comments Characteristics: Retains ER expression and hormonal responsiveness (PubMed=36396974).
Characteristics: Established from a mouse xenograft (EC-PDX-23) (PubMed=36396974).
Doubling time: ~30 hours (PubMed=36396974).
Microsatellite instability: Instable (MSI-high) (PubMed=36396974).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gly801Valfs*32 (c.2402delG); Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Gln2070Ter (c.6208C>T); Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:15840; KMT2B; Simple; p.Gly1733Trpfs*6 (c.5196dupT); Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Ser4327Glnfs*7 (c.12978dupG); Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:14234; NSD1; Simple; p.Met1531Cysfs*43 (c.4591delA); Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu39Lys (c.115G>A); ClinVar=VCV003258061; Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Arg93Gln (c.278G>A); ClinVar=VCV000419128; Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg130Gly (c.388C>G); ClinVar=VCV000375958; Zygosity=Unspecified (PubMed=36396974).
  • Mutation; HGNC; HGNC:777; ZFHX3; Simple; p.Arg2693Ter (c.8077C>T); Zygosity=Unspecified (PubMed=36396974).
Disease Type I endometrial adenocarcinoma (NCIt: C40145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC641

Markers:
AmelogeninX
CSF1PO12,13
D3S135816,17
D5S81811
D7S82010,11
D8S117912,13,14
D13S31711,12
D16S53911,12
D18S5112,15
D21S1128,29
FGA20,24,25
Penta D11,12
Penta E12,15
TH019.3,10
TPOX8,9
vWA17,19,20

Run an STR similarity search on this cell line
Publications

PubMed=36396974; DOI=10.1038/s41598-022-24211-8; PMCID=PMC9672046
Rush C.M., Blanchard Z., Polaski J.T., Osborne K.S., Osby K., Vahrenkamp J.M., Yang C.-H., Lum D.H., Hagan C.R., Leslie K.K., Pufall M.A., Thiel K.W., Gertz J.
Characterization of HCI-EC-23 a novel estrogen- and progesterone-responsive endometrial cancer cell line.
Sci. Rep. 12:19731.1-19731.17(2022)

Cross-references
Cell line collections (Providers) Millipore; SCC641
Gene expression databases GEO; GSM6421755
GEO; GSM6421756
GEO; GSM6421757
GEO; GSM6421761
GEO; GSM6421762
GEO; GSM6421763
GEO; GSM6421764
GEO; GSM6421765
GEO; GSM6421766
GEO; GSM6421767
GEO; GSM6421768
GEO; GSM6727284
GEO; GSM6727285
Entry history
Entry creation19-Dec-2024
Last entry update10-Apr-2025
Version number2