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Cellosaurus T137p53i (CVCL_E3FZ)

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Cell line name T137p53i
Accession CVCL_E3FZ
Resource Identification Initiative To cite this cell line use: T137p53i (RRID:CVCL_E3FZ)
Comments Knockout cell: Method=shRNA knockdown; HGNC; HGNC:11998; TP53.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Ovary, surface epithelium; UBERON=UBERON_0001304.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Telomerase immortalized cell line
Publications

PubMed=16829690; DOI=10.1093/carcin/bgl115
Gong Yang, Daniel Gustavo Rosen, Imelda Mercado-Uribe, Justin Adam Colacino, Gordon B. Mills, Robert Clinton Bast Jr., Chen-Yi Zhou, Jin-Song Liu;
Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Carcinogenesis 28:174-182(2007)

Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number2