Cellosaurus cell line SK-OV-3/pVgRXR (CVCL

Cellosaurus SK-OV-3/pVgRXR (CVCL_E3E8)

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Cell line name

SK-OV-3/pVgRXR

Synonyms

SK-OV-3 Zeo(R); SK-OV-3 ZeoR

Accession

CVCL_E3E8

Resource Identification Initiative

To cite this cell line use: SK-OV-3/pVgRXR (RRID:CVCL_E3E8)

Comments

Population: Caucasian.
Characteristics: Transfected with the pVgRXR vector that contains the VgEcR fusion protein under the control of a CMV promoter and RXRA under the control of a RSV promoter as well as BleoR (PubMed=15755800).
Genetic integration: Method=Transfection; Gene=FlyBase_Gene; FBgn0000546; EcR (Note=With p.Met1_Val221del, as 2nd part of VgECR).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:10477; RXRA.
Genetic integration: Method=Transfection; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Thr412del, as 1st part of VgECR).
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.

Sequence variations

Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).

Disease

Ovarian serous cystadenocarcinoma (NCIt: C7978)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0532 (SK-OV-3)
Children:

CVCL_E3E9 (SK-OV-3/pVgRXR/pIND)

CVCL_E3EA (SK-OV-3/pVgRXR/pINDp53wt)

Sex of cell

Female

Age at sampling

64Y