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Cellosaurus MSA-21 pB-rtTA(#4)-NFIB-mKate2 (CVCL_E3D2)

[Text version]
Cell line name MSA-21 pB-rtTA(#4)-NFIB-mKate2
Accession CVCL_E3D2
Resource Identification Initiative To cite this cell line use: MSA-21 pB-rtTA(#4)-NFIB-mKate2 (RRID:CVCL_E3D2)
Comments Part of: Mass General Brigham Stem Cells in Neurodegeneration [SCiN] panel.
Characteristics: Transposed with a piggyBac-rtTA(TRE4G)-NFIB-mKate2 construct (PubMed=39079530).
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:7785; NFIB.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=ZFN; Gene=FPbase; DBBO8; mKate2 (Note=Bright red fluorescent protein derived from eqFP578).
Derived from site: In situ; Ankle, skin; UBERON=UBERON_0001512.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Multiple system atrophy (NCIt: C84909)
Multiple system atrophy (ORDO: Orphanet_102)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3CW (MSA-21)
Sex of cell Male
Age at sampling 68Y
Category Induced pluripotent stem cell
Publications

PubMed=39079530; DOI=10.1016/j.neuron.2024.06.002; PMCID=PMC11377155
Isabel Lam, Alain Ndayisaba, Amanda Jennifer Lewis, Yu-Hong Fu, Giselle T. Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo Luis Sanz, Aazam Vahdatshoar ...Show all 54 authors... , Timothy D. Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schabinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zi-Chen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xin-Yuan Wang, Thorold W. Theunissen, Hao-Yi Wang, Rudolf Jaenisch, Susan Lee Lindquist, Beth Stevens, Nadia Stefanova, Gregor Karl Wenning, Wilma D.J. van de Berg, Kelvin C. Luk, Rosario Sanchez-Pernaute, Juan Carlos Gomez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, Song Stephen Yi, Chee-Yeun Chung, Henning Stahlberg, Isidre Ferrer, Johannes Schoneberg, Stephen Joseph Elledge, Ulf Dettmer, Glenda Margaret Halliday, Tim Bartels, Vikram Khurana; Show fewer authors
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of alpha-synuclein inclusions.
Neuron 112:2886-2909.e16(2024)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number4