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Cellosaurus ND34391 clone E2 (CVCL_E3CD)

[Text version]
Cell line name ND34391 clone E2
Accession CVCL_E3CD
Resource Identification Initiative To cite this cell line use: ND34391 clone E2 (RRID:CVCL_E3CD)
Comments Population: Caucasian.
Characteristics: Transposed with a piggyBac-rtTA(TRE4G)-NGN2-T2A-PuroR-IRES-SNAP-tag construct (PubMed=35688132).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11138; SNCA (Note=4 of the 4 copies).
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:7059; MGMT (Note=With p.Gly180_Asn207del and 19 mutations = SNAP-tag).
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:13805; NEUROG2.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
Cell type: Fibroblast of skin; CL=CL_0002620.
Disease Parkinson disease 4, autosomal dominant (NCIt: C198604)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_E3CC (ND34391 clone C6)
Sex of cell Female
Age at sampling 55Y
Category Induced pluripotent stem cell
Publications

PubMed=35688132; DOI=10.1016/j.cell.2022.05.008; PMCID=PMC9394447
Erinc Hallacli, Can Kayatekin, Sumaiya Nazeen, Xiou-H. Wang, Zoe Sheinkopf, Shubhangi Sathyakumar, Souvarish Sarkar, Xin Jiang, Xian-Jun Dong, Roberto Di Maio, Wen Wang ...Show all 27 authors... , Matthew T. Keeney, Daniel Felsky, Jackson Sandoe, Aazam Vahdatshoar, Namrata D. Udeshi, D.R. Mani, Steven A. Carr, Susan Lee Lindquist, Philip Lawrence De Jager, David P. Bartel, Chad L. Myers, J. Timothy Greenamyre, Mel B. Feany, Shamil Rashidovich Sunyaev, Chee-Yeun Chung, Vikram Khurana; Show fewer authors
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.
Cell 185:2035-2056.e33(2022)

PubMed=39079530; DOI=10.1016/j.neuron.2024.06.002; PMCID=PMC11377155
Isabel Lam, Alain Ndayisaba, Amanda Jennifer Lewis, Yu-Hong Fu, Giselle T. Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo Luis Sanz, Aazam Vahdatshoar ...Show all 54 authors... , Timothy D. Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schabinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zi-Chen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xin-Yuan Wang, Thorold W. Theunissen, Hao-Yi Wang, Rudolf Jaenisch, Susan Lee Lindquist, Beth Stevens, Nadia Stefanova, Gregor Karl Wenning, Wilma D.J. van de Berg, Kelvin C. Luk, Rosario Sanchez-Pernaute, Juan Carlos Gomez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, Song Stephen Yi, Chee-Yeun Chung, Henning Stahlberg, Isidre Ferrer, Johannes Schoneberg, Stephen Joseph Elledge, Ulf Dettmer, Glenda Margaret Halliday, Tim Bartels, Vikram Khurana; Show fewer authors
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of alpha-synuclein inclusions.
Neuron 112:2886-2909.e16(2024)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number4