Cellosaurus RAW 264.7 Lrrk2 KO + HALO-human LRRK2 LIR1 mutant + HA-human GABARAP (CVCL_E2WZ)
| Cell line name | RAW 264.7 Lrrk2 KO + HALO-human LRRK2 LIR1 mutant + HA-human GABARAP |
|---|---|
| Synonyms | RAW 264.7 LRRK2KO + HALO-LRRK2 (LIR1 mutant, human) + HA-Gabarap (human) |
| Accession | CVCL_E2WZ |
| Resource Identification Initiative | To cite this cell line use: RAW 264.7 Lrrk2 KO + HALO-human LRRK2 LIR1 mutant + HA-human GABARAP (RRID:CVCL_E2WZ) |
| Comments | Knockout cell: Method=ZFN; MGI; MGI:1913975; Lrrk2. Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:4067; GABARAP (Note=With a N-terminal HA tag). Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:18618; LRRK2 (Note=With p.Trp109Ala and p.Leu112Ala = LIR1 mutant). Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P33967; Bacillus cereus Bsr. Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P0A3G2; Rhodococcus rhodochrous dhaA (Note=Mutated = HaloTag). Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR). Transformant: NCBI_TaxID; 11788; Abelson mouse leukemia virus (AbMuLV). Derived from site: In situ; Ascites; UBERON=UBERON_0007795. Cell type: Macrophage; CL=CL_0000235. |
| Disease | Mouse leukemia (NCIt: C21604) |
| Species of origin | Mus musculus (Mouse)
(NCBI Taxonomy: 10090)
Breed/subspecies: BALB/c. |
| Hierarchy | Parent: CVCL_E2WY (RAW 264.7 Lrrk2 KO + HA-human GABARAP) |
| Sex of cell | Male |
| Age at sampling | Adult |
| Category | Cancer cell line |
| Publications | PubMed=39812709; DOI=10.1083/jcb.202310150; PMCID=PMC11734622 |
| Entry history | |
| Entry creation | 10-Sep-2024 |
| Last entry update | 27-Nov-2025 |
| Version number | 3 |