Cellosaurus cell line HCB-541 (CVCL

Cellosaurus HCB-541 (CVCL_E2T2)

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Cell line name

HCB-541

Synonyms

Hospital de Cancer de Barretos-541

Accession

CVCL_E2T2

Resource Identification Initiative

To cite this cell line use: HCB-541 (RRID:CVCL_E2T2)

Comments

Doubling time: 19-22 hours (PubMed=38565739).
Microsatellite instability: Instable (MSI-high) (PubMed=38565739).
Derived from site: In situ; Axilla, skin; UBERON=UBERON_0015474.

Sequence variations

Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61His (c.183G>T); ClinVar=VCV000376318; Zygosity=Heterozygous (PubMed=38565739).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=38565739).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Leu (c.743G>T); ClinVar=VCV000230253; Zygosity=Homozygous (PubMed=38565739).

Disease

Skin squamous cell carcinoma (NCIt: C4819)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

67Y

Category

Cancer cell line

STR profile

Source(s): PubMed=38565739

Markers:

Amelogenin	X
CSF1PO	11,12
D5S818	11
D7S820	10,11
D13S317	11
D16S539	11,12
TH01	9,9.3
TPOX	6,8,11
vWA	15,19

Publications

PubMed=38565739; DOI=10.1007/s13577-024-01054-1; PMCID=PMC11194207
Ana Carolina Laus, Izabela Natalia Faria Gomes, Aline Larissa Virginio da Silva, Luciane Sussuchi da Silva, Mirella Baroni Milan, Silvia Aparecida Teixeira, Ana Carolina Baptista Moreno Martin, Leticia do Nascimento Braga Pereira, Carlos Eduardo Barbosa de Carvalho, Camila de Souza Crovador, Flavia Escremin de Paula ...Show all 16 authors... , Flavia Caroline Nascimento, Helder Teixeira de Freitas, Vinicius de Lima Vazquez, Rui Manuel Reis, Renato Jose da Silva-Oliveira; Show fewer authors
Establishment and molecular characterization of HCB-541, a novel and aggressive human cutaneous squamous cell carcinoma cell line.
Hum. Cell 37:1170-1183(2024)

Entry history

Entry creation

10-Sep-2024

Last entry update

19-Dec-2024

Version number