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Cellosaurus MDA-MB-231GFP (CVCL_E2QK)

[Text version]
Cell line name MDA-MB-231GFP
Accession CVCL_E2QK
Resource Identification Initiative To cite this cell line use: MDA-MB-231GFP (RRID:CVCL_E2QK)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Doubling time: ~24-48 hours (DSMZ=ACC-981).
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-981

Markers:
AmelogeninX
CSF1PO12,13,14
D2S133820,21
D3S135816
D5S81812
D7S8208,9
D8S117913
D13S31713
D16S53912
D18S5111
D19S43311,14
D21S1133.2
FGA22
Penta D14
Penta E11
TH017,9.3
TPOX8,9
vWA15,18

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Publications

PubMed=23895436; DOI=10.1089/scd.2013.0249
Katharina Mandel, Yuan-Yuan Yang, Axel Schambach, Silke Glage, Anna Otte, Ralf Hass;
Mesenchymal stem cells directly interact with breast cancer cells and promote tumor cell growth in vitro and in vivo.
Stem Cells Dev. 22:3114-3127(2013)

PubMed=29569804; DOI=10.1002/stem.2819
Catharina Melzer, Juliane von der Ohe, Ralf Hass;
In vitro fusion of normal and neoplastic breast epithelial cells with human mesenchymal stroma/stem cells partially involves tumor necrosis factor receptor signaling.
Stem Cells 36:977-989(2018)

Cross-references
Cell line collections (Providers) DSMZ; ACC-981
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2