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Cellosaurus HyCyte NCI-H446 hHFE_p.C282Y_c.845G>A (CVCL_E2Q8)

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Cell line name HyCyte NCI-H446 hHFE_p.C282Y_c.845G>A
Synonyms hHFE_p.C282Y_c.845G>A NCI-H446
Accession CVCL_E2Q8
Resource Identification Initiative To cite this cell line use: HyCyte NCI-H446 hHFE_p.C282Y_c.845G>A (RRID:CVCL_E2Q8)
Comments Population: Caucasian.
Doubling time: 48-72 hours (Hysigen=CGKO-M2154).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:6728; LY6H + HGNC; HGNC:9709; PVT1; Name(s)=PVT1-LY6H (from parent cell line).
  • Mutation; HGNC; HGNC:4886; HFE; Simple_edited; p.Cys282Tyr (c.845G>A); ClinVar=VCV000000009; Zygosity=Homozygous; Note=By CRISPR/Cas9 (Hysigen=CGMU-M2154).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly154Val (c.461G>T); ClinVar=VCV000651769; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1562 (NCI-H446)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGMU-M2154
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2