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Cellosaurus HAP1 EIF2AK1 (-) EIF2AK3 (-) 2 (CVCL_E1NR)

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Cell line name HAP1 EIF2AK1 (-) EIF2AK3 (-) 2
Synonyms HZGHC008248c036; Double knockout cell line EIF2AK1 1bp deletion in exon 2 and EIF2AK3 29bp deletion in exon 5
Accession CVCL_E1NR
Resource Identification Initiative To cite this cell line use: HAP1 EIF2AK1 (-) EIF2AK3 (-) 2 (RRID:CVCL_E1NR)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:24921; EIF2AK1.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3255; EIF2AK3.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_SL63 (HAP1 EIF2AK1 (-))
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC008248c036
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2