Cellosaurus cell line Ubigene SW480 FBXW7 KO (CVCL

Cross-references
Cell line name	Ubigene SW480 FBXW7 KO
Synonyms	FBXW7 Knockout cell line (SW480)
Accession	CVCL_E1CF
Resource Identification Initiative	To cite this cell line use: Ubigene SW480 FBXW7 KO (RRID:CVCL_E1CF)
Comments	Population: Caucasian. Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:16712; FBXW7. Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease	Colon adenocarcinoma (NCIt: C4349)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0546 (SW480)
Sex of cell	Male
Age at sampling	51Y
Category	Cancer cell line
Cell line collections (Providers)	Ubigene; YKO-H499
Entry history
Entry creation	10-Sep-2024
Last entry update	19-Dec-2024
Version number	2