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Cellosaurus HAP1 Cas9 (CVCL_DX72)

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Cell line name HAP1 Cas9
Accession CVCL_DX72
Resource Identification Initiative To cite this cell line use: HAP1 Cas9 (RRID:CVCL_DX72)
Comments Group: Haploid karyotype cell line.
Characteristics: Transduced with a lentiviral vector EF1a-Bsd-T2A-Cas9-WPRE (Horizon_Discovery=HD+Cas9-011).
Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Transfected with: UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_Y019 (HAP1)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+Cas9-011
Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1