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Cellosaurus HAP1 ACAD10 (-) ACAD11 (-) (CVCL_DX20)

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Cell line name HAP1 ACAD10 (-) ACAD11 (-)
Synonyms HZGHC007789c010; Double knockout cell line ACAD10 11bp deletion in exon 2 and ACAD11 1bp insertion in exon 4
Accession CVCL_DX20
Resource Identification Initiative To cite this cell line use: HAP1 ACAD10 (-) ACAD11 (-) (RRID:CVCL_DX20)
Comments Group: Haploid karyotype cell line.
Knockout cell: Method=CRISPR/Cas9; HGNC; 21597; ACAD10.
Knockout cell: Method=CRISPR/Cas9; HGNC; 30211; ACAD11.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XK96 (HAP1 ACAD10 (-) 2)
Sex of cell Male
Age at sampling 40Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HZGHC007789c010
Entry history
Entry creation30-Jan-2024
Last entry update30-Jan-2024
Version number1