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Cellosaurus MCF-7/Twist (CVCL_DR99)

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Cell line name MCF-7/Twist
Accession CVCL_DR99
Resource Identification Initiative To cite this cell line use: MCF-7/Twist (RRID:CVCL_DR99)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:12428; TWIST1.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=16322226; DOI=10.1158/0008-5472.CAN-05-0712; PMCID=PMC5575828
Yelena Mironchik, Paul T. Winnard Jr., Farhad Vesuna, Yoshinori Kato, Flonne Wildes, Arvind P. Pathak, Scott L. Kominsky, Dmitri Artemov, Zaver Bhujwalla, Paul Van Diest, Horst Burger ...Show all 13 authors... , Carlotta Glackin, Venu Raman; Show fewer authors
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.
Cancer Res. 65:10801-10809(2005)

PubMed=20019840; DOI=10.1593/neo.91084; PMCID=PMC2794513
Farhad Vesuna, Ala Lisok, Brian Kimble, Venu Raman;
Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression.
Neoplasia 11:1318-1328(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DR99
Encyclopedic resources Wikidata; Q54904396
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number14