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Cellosaurus (CVCL_DQ38)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: MD Anderson Cell Lines Project.
Part of: NCI-60 cancer cell line panel.
Population: Caucasian.
Doubling time: 45 hours (PubMed=721102); 24 hours (PubMed=25984343); ~24 hours (CLS=300107); 22.4 hours (NCI-DCTD=786-0).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; Fluorescent probe library screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; GPI-anchored proteins.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Misspelling: 768-0; Note=Occasionally.
Misspelling: 796-0; Note=Occasionally.
Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gln149Ter (c.445C>T); ClinVar=VCV000404164; Zygosity=Homozygous (PubMed=17088437; Cosmic-CLP=905947; DepMap=ACH-000649).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.560-2A>G; ClinVar=VCV003148158; Zygosity=Heterozygous; Note=Splice acceptor mutation (Cosmic-CLP=905947; DepMap=ACH-000649).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Ala (c.832C>G); ClinVar=VCV000376645; Zygosity=Heterozygous (PubMed=9331090; Cosmic-CLP=905947; DepMap=ACH-000649).
  • Mutation; HGNC; HGNC:12687; VHL; Simple; p.Gly104Alafs*55 (c.311delG); Zygosity=Homozygous (PubMed=7915601; PubMed=17088437; Cosmic-CLP=905947; DepMap=ACH-000649).
HLA typing Source: PubMed=15585611
Class I
HLA-AA*03
HLA-BB*07,44

Source: PubMed=15748285
Class I
HLA-AA*03:01:01
HLA-BB*07,44
HLA-CC*05,07:02:01
Class II
HLA-DPDPB1*04:02
HLA-DQDQB1*06,06
HLA-DRDRB1*13,15

Source: PubMed=26589293
Class I
HLA-AA*03:01,03:01
HLA-BB*07:02,44:02
HLA-CC*05:01,07:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.77
Native American0
East Asian, North4.36
East Asian, South0
South Asian0
European, North65.75
European, South29.12
Disease Renal cell carcinoma (NCIt: C9385)
Renal cell carcinoma (ORDO: Orphanet_217071)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1932; CCRID; CLS=300107; Cosmic-CLP=905947; IZSLER=BS TCL 124; PubMed=19372543; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D2S133817,18
D3S135816
D5S8189
D7S82011,12
D8S117913
D13S3178
D16S53912
D18S5113,14
D19S43314,15
D21S1129,30
FGA24 (ATCC=CRL-1932; CCRID; PubMed=19372543; PubMed=25877200)
24,25 (CLS=300107)
Penta D9,12
Penta E7,16
TH016,9.3
TPOX8,11
vWA15,17

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Entry history
Entry creation04-Apr-2012
Last entry update25-Jun-2026
Version number51