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Cellosaurus KCL22-r (CVCL_DP58)

[Text version]
Cell line name KCL22-r
Synonyms KCL22-R; KCL22R
Accession CVCL_DP58
Resource Identification Initiative To cite this cell line use: KCL22-r (RRID:CVCL_DP58)
Comments Population: Japanese.
Doubling time: ~24-30 hours (ATCC=CRL-3350).
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Omics: Proteomics; 2DE-MS.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Leufs*5 (c.3261dupC) (3261_3262insC); ClinVar=VCV000089364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro301Glnfs*44 (c.902delC); ClinVar=VCV000233908; Zygosity=Homozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2091 (KCL-22)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3350

Markers:
AmelogeninX
CSF1PO12
D5S81810,11
D7S82012
D13S31711
D16S53912
TH017,9
TPOX8
vWA14

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Publications

PubMed=10910924; DOI=10.1182/blood.V96.3.1070
Francois-Xavier Mahon, Michael W.N. Deininger, Beate Schultheis, Jerome Chabrol, Josy Reiffers, John Michael Goldman, Junia Vaz de Melo;
Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.
Blood 96:1070-1079(2000)

PubMed=17549412; DOI=10.3892/ijo.31.1.121
Julia Hentschel, Anja Weise, Susanne Michel, Katrin Hennig, Isabell Hartmann, Jana Schiefner, Katrin Schubert, Thomas Liehr, Ferdinand von Eggeling, Ivan Francisco Loncarevic;
Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R.
Int. J. Oncol. 31:121-128(2007)

PubMed=20417730; DOI=10.1016/j.bbapap.2010.04.009
Irene Colavita, Nicola Esposito, Rosanna Martinelli, Francesca Catanzano, Junia Vaz de Melo, Fabrizio Pane, Margherita Ruoppolo, Francesco Salvatore;
Gaining insights into the Bcr-Abl activity-independent mechanisms of resistance to imatinib mesylate in KCL22 cells: a comparative proteomic approach.
Biochim. Biophys. Acta 1804:1974-1987(2010)

PubMed=23754495; DOI=10.1002/pmic.201200444
Irene Colavita, Nicola Esposito, Concetta Quintarelli, Ersilia Nigro, Fabrizio Pane, Margherita Ruoppolo, Francesco Salvatore;
Identification of annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells.
Proteomics 13:2414-2418(2013)

Cross-references
Cell line collections (Providers) ATCC; CRL-3350
Cell line databases/resources cancercelllines; CVCL_DP58
Encyclopedic resources Wikidata; Q54899693
Proteomic databases PRIDE; PXD000030
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number14