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Cellosaurus MCF7/LCC9 (CVCL_DP52)

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Cell line name MCF7/LCC9
Synonyms MCF-7/LCC9; LCC9
Accession CVCL_DP52
Resource Identification Initiative To cite this cell line use: MCF7/LCC9 (RRID:CVCL_DP52)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_31638; Fulvestrant (ICI 182780).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DP50 (MCF7/LCC1)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9270017
Nils Brunner, Birgitte Boysen, Stana Jirus, Todd C. Skaar, Claus Holst-Hansen, Jeremy Lippman, Thomas L. Frandsen, Mogens Spang-Thomsen, Suzanne A.W. Fuqua, Robert Clarke;
MCF7/LCC9: an antiestrogen-resistant MCF-7 variant in which acquired resistance to the steroidal antiestrogen ICI 182,780 confers an early cross-resistance to the nonsteroidal antiestrogen tamoxifen.
Cancer Res. 57:3486-3493(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DP52
Anatomy/cell type resources BTO; BTO_0005970
Encyclopedic resources Wikidata; Q54904470
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number14