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Cellosaurus MDA-BoM-1833 (CVCL_DP48)

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Cell line name MDA-BoM-1833
Synonyms MDA 231 BoM 1833; BoM-1833; 1833 BoM; MDA-MB-231 1833 BoM; MDA-MB-231-1833; MDA-MB-231 subline 1833; MDA-MB-231 Bone Tropic 1833 subclone; 1833
Accession CVCL_DP48
Resource Identification Initiative To cite this cell line use: MDA-BoM-1833 (RRID:CVCL_DP48)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Established from bone metastasis of nude mice inculated with the parent cell line.
Omics: Proteomics; 2DE.
Omics: Proteomics; Subcellular; Secretome.
Miscellaneous: STR profile from MSKCC antibody and bioresource core facility.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): MSKCC

Markers:
AmelogeninX
CSF1PO12,13
D2S133820,21
D3S135816
D5S81812
D7S8208
D8S117913
D13S31713
D16S53912
D18S5111,16
D19S43311
D21S1130,33.2
FGA22,23
TH017,9.3
TPOX8,9
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=12842083; DOI=10.1016/S1535-6108(03)00132-6
Yi-Bin Kang, Peter M. Siegel, Wei-Ping Shu, Maria Drobnjak, Sanna-Maria Kakonen, Carlos Cordon-Cardo, Theresa A. Guise, Joan Massague;
A multigenic program mediating breast cancer metastasis to bone.
Cancer Cell 3:537-549(2003)

PubMed=18425382; DOI=10.3892/or.19.5.1237
Irena Selicharova, Miloslav Sanda, Jana Mladkova, Sujata Saraswat Ohri, Aruna Vashishta, Martin Fusek, Jiri Jiracek, Vaclav Vetvicka;
2-DE analysis of breast cancer cell lines 1833 and 4175 with distinct metastatic organ-specific potentials: comparison with parental cell line MDA-MB-231.
Oncol. Rep. 19:1237-1244(2008)

PubMed=26649326; DOI=10.1016/j.dib.2015.09.039; PMCID=PMC4644255
Thomas R. Cox, Erwin M. Schoof, Alison Gartland, Janine T. Erler, Rune Linding;
Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.
Data Brief 5:621-625(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DP48
Encyclopedic resources Wikidata; Q54904574
Proteomic databases PRIDE; PXD000397
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number20