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Cellosaurus HCC827 PFR6 (CVCL_DH96)

[Text version]
Cell line name HCC827 PFR6
Synonyms HCC827 PFR-6
Accession CVCL_DH96
Resource Identification Initiative To cite this cell line use: HCC827 PFR6 (RRID:CVCL_DH96)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:132268; Dacomitinib (PF-00299804).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=20129249; DOI=10.1016/j.ccr.2009.11.022
Schrock A.B., Zejnullahu K., Wu Y.-L., Song Y., Dias-Santagata D., Lifshits E., Toschi L., Rogers A., Mok T., Sequist L.V., Lindeman N.I., Murphy C., Akhavanfard S., Yeap B.Y., Xiao Y., Capelletti M., Iafrate A.J., Lee C., Christensen J.G., Engelman J.A., Janne P.A.
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.
Cancer Cell 17:77-88(2010)

Cell line databases/resources cancercelllines; CVCL_DH96
Encyclopedic resources Wikidata; Q54881799
Gene expression databases GEO; GSM466330
Polymorphism and mutation databases Progenetix; CVCL_DH96
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12