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Cellosaurus HCC827 PFR5 (CVCL_DH95)

[Text version]
Cell line name HCC827 PFR5
Synonyms HCC827 PFR-5
Accession CVCL_DH95
Resource Identification Initiative To cite this cell line use: HCC827 PFR5 (RRID:CVCL_DH95)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_132268; Dacomitinib (PF-00299804).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
Publications

PubMed=20129249; DOI=10.1016/j.ccr.2009.11.022; PMCID=PMC2980857
Alexa B. Schrock, Kreshnik Zejnullahu, Yi-Long Wu, Youngchul Song, Dora Dias-Santagata, Eugene Lifshits, Luca Toschi, Andrew Rogers, Tony Mok, Lecia VanDam Sequist, Neal I. Lindeman ...Show all 21 authors... , Carly Murphy, Sara Akhavanfard, Beow Yong Yeap, Yun Xiao, Marzia Capelletti, Anthony John Iafrate, Charles Lee, James Gail Christensen, Jeffrey Adam Engelman, Pasi Antero Janne; Show fewer authors
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.
Cancer Cell 17:77-88(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH95
Encyclopedic resources Wikidata; Q54881798
Gene expression databases GEO; GSM466329
Polymorphism and mutation databases Progenetix; CVCL_DH95
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number13