Cellosaurus cell line MGH119-R (CVCL

Cellosaurus MGH119-R (CVCL_DH48)

Cross-references
Cell line name	MGH119-R
Synonyms	MGH119-GR
Accession	CVCL_DH48
Resource Identification Initiative	To cite this cell line use: MGH119-R (RRID:CVCL_DH48)
Comments	Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa). Omics: Transcriptomics; Microarray.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified (PubMed=25758528). Mutation; HGNC; HGNC:3236; EGFR; Unexplicit; Ex19del; Zygosity=Unspecified (PubMed=25758528).
Disease	Lung non-small cell carcinoma (NCIt: C2926)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_DH47 (MGH119)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=25758528; DOI=10.1038/ncomms7377; PMCID=PMC4357281 Matthew J. Niederst, Lecia VanDam Sequist, John T. Poirier, Craig H. Mermel, Elizabeth L. Lockerman, Angel R. Garcia, Ryohei Katayama, Carlotta Costa, Kenneth N. Ross, Teresa Moran, Emily Howe ...Show all 27 authors... , Linnea E. Fulton, Hillary E. Mulvey, Lindsay A. Bernardo, Farhiya Mohamoud, Norikatsu Miyoshi, Paul A. VanderLaan, Daniel Botelho Costa, Pasi Antero Janne, Darrell R. Borger, Sridhar Ramaswamy, Toshi Shioda, Anthony John Iafrate, Gad Getz, Charles M. Rudin, Mari Mino-Kenudson, Jeffrey Adam Engelman; Show fewer authors RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Nat. Commun. 6:6377.1-6377.10(2015)
Encyclopedic resources	Wikidata; Q54905472
Gene expression databases	GEO; GSM1568546
Entry history
Entry creation	13-Jul-2016
Last entry update	10-Apr-2025
Version number	8