| Cell line name |
451Lu-MR |
|---|
| Accession |
CVCL_DG54 |
|---|
| Resource Identification Initiative |
To cite this cell line use: 451Lu-MR (RRID:CVCL_DG54) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_75998; Trametinib (Mekinist; GSK1120212).
Derived from site: Metastatic; Arm, skin; UBERON=UBERON_0002427. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61fs*59 (c.179dupC) (p.Gly75fs, c.222dupC); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Cutaneous melanoma (NCIt: C3510) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_6357 (451Lu) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
22Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=24055054; DOI=10.1016/j.celrep.2013.08.023; PMCID=PMC3956616
Jessie Villanueva, Jeffrey R. Infante, Clemens Krepler, Patricia Reyes-Uribe, Minu Samanta, Hsin-Yi Chen, Bin Li, Rolf K. Swoboda, Melissa Wilson, Adina Vultur, Mizuho Fukunaga-Kalabis ...Show all 28 authors... , Bradley Wubbenhorst, Thomas Y. Chen, Qin Liu, Katrin Sproesser, Douglas J. DeMarini, Tona Morgan Gilmer, Anne-Marie Martin, Ronen Marmorstein, David C. Schultz, David W. Speicher, Giorgos Constantine Karakousis, Wei Xu, Ravi K. Amaravadi, Xiao-Wei Xu, Lynn Mara Schuchter, Meenhard Herlyn, Katherine L. Nathanson; Show fewer authors
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma.
Cell Rep. 4:1090-1099(2013) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_DG54
|
|---|
| Encyclopedic resources |
Wikidata; Q54603182
|
|---|
| Gene expression databases |
GEO; GSM1199179
|
|---|
| Polymorphism and mutation databases |
Progenetix; CVCL_DG54
|
|---|
| Entry history |
|---|
| Entry creation | 13-Jul-2016 |
|---|
| Last entry update | 19-Dec-2024 |
|---|
| Version number | 14 |
|---|
