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Cellosaurus HCC827/WR (CVCL_DG26)

[Text version]
Cell line name HCC827/WR
Accession CVCL_DG26
Resource Identification Initiative To cite this cell line use: HCC827/WR (RRID:CVCL_DG26)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2063 (HCC827)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line

PubMed=26980747; DOI=10.18632/oncotarget.8013
Park J.H., Choi Y.J., Kim S.Y., Lee J.-E., Sung K.J., Park S., Kim W.S., Song J.S., Choi C.-M., Sung Y.H., Rho J.K., Lee J.C.
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.
Oncotarget 7:22005-22015(2016)

Cell line databases/resources cancercelllines; CVCL_DG26
Encyclopedic resources Wikidata; Q54881807
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number12