| Cell line name |
H1975/WR |
|---|
| Accession |
CVCL_DG25 |
|---|
| Resource Identification Initiative |
To cite this cell line use: H1975/WR (RRID:CVCL_DG25) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:61400; WZ4002.
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
|---|
| Sequence variations |
- Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Lung adenocarcinoma (NCIt: C3512) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_1511 (NCI-H1975) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
Age unspecified |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=26980747; DOI=10.18632/oncotarget.8013
Park J.H., Choi Y.J., Kim S.Y., Lee J.-E., Sung K.J., Park S., Kim W.S., Song J.S., Choi C.-M., Sung Y.H., Rho J.K., Lee J.C.
Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.
Oncotarget 7:22005-22015(2016) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_DG25
|
|---|
| Encyclopedic resources |
Wikidata; Q54871980
|
|---|
| Entry history |
|---|
| Entry creation | 13-Jul-2016 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 10 |
|---|
