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Cellosaurus MDA231-LM2-4142 (CVCL_DG21)

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Cell line name MDA231-LM2-4142
Synonyms MDA 231-LM2-4142; MDA-MB-231 #4142; LM2-4142; 4142
Accession CVCL_DG21
Resource Identification Initiative To cite this cell line use: MDA231-LM2-4142 (RRID:CVCL_DG21)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: Caucasian.
Characteristics: Established from MDA231-TGL cell line after 3 passage in nude mice.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR35 (MDA231-TGL)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=16049480; DOI=10.1038/nature03799; PMCID=PMC1283098
Andy J. Minn, Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Wei-Ping Shu, Dilip D. Giri, Agnes J. Viale, Adam B. Olshen, William Levi Gerald, Joan Massague;
Genes that mediate breast cancer metastasis to lung.
Nature 436:518-524(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG21
Encyclopedic resources Wikidata; Q54904665
Gene expression databases GEO; GSM50017
GEO; GSM587389
Entry history
Entry creation13-Jul-2016
Last entry update14-Aug-2025
Version number20