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Cellosaurus (CVCL_DE17)

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Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Variations; SNP array analysis.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Children:
CVCL_4536 (L-M(TK-))
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1002; RCB=RCB1898; TKG=TKG 0211

Markers:

Run an STR similarity search on this cell line
Publications





Louis Guillou, Philippe Terrier, Alain Aurias;
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas.
Cancer Res. 69:2269-2278(2009)

Cross-references
Cell line collections (Providers) TKG; TKG 0211
Encyclopedic resources Wikidata; Q54899403
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number29