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Cellosaurus C3 [Mouse HPV16 transformed] (CVCL_DC63)

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Cell line name C3 [Mouse HPV16 transformed]
Accession CVCL_DC63
Resource Identification Initiative To cite this cell line use: C3 [Mouse HPV16 transformed] (RRID:CVCL_DC63)
Comments Virology: Tumorigenic. Probably contains a complete HPV16 genome (PubMed=7690326).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Children:
CVCL_A7FZ (C3-luc)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Transformed cell line
Publications

PubMed=7690326; DOI=10.1002/eji.1830230929
Mariet C.W. Feltkamp, Henk L. Smits, Michel P.M. Vierboom, Rene P. Minnaar, Barteld M. de Jongh, Jan Wouter Drijfhout, Jan ter Schegget, Cornelis Joseph Maria Melief, W. Martin Kast;
Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells.
Eur. J. Immunol. 23:2242-2249(1993)

PubMed=21439369; DOI=10.1016/j.mcp.2011.03.003
Markus Schmitt, Michael Pawlita;
The HPV transcriptome in HPV16 positive cell lines.
Mol. Cell. Probes 25:108-113(2011)

PubMed=26900913; DOI=10.1371/journal.pone.0149748; PMCID=PMC4763794
Li-Li Li, He-Rong Wang, Zhi-Yi Zhou, Jing Luo, Xiao-Li Wang, Xiang-Qian Xiao, Yu-Bai Zhou, Yi Zeng;
C3-Luc cells are an excellent model for evaluation of cellular immunity following HPV16L1 vaccination.
PLoS ONE 11:e0149748.1-e0149748.15(2016)

Cross-references
Encyclopedic resources Wikidata; Q54808130
Entry history
Entry creation13-Jul-2016
Last entry update27-Nov-2025
Version number11