Cellosaurus cell line MLEL1.1c1 (CVCL

Cellosaurus MLEL1.1c1 (CVCL_DC34)

Cross-references
Cell line name	MLEL1.1c1
Accession	CVCL_DC34
Resource Identification Initiative	To cite this cell line use: MLEL1.1c1 (RRID:CVCL_DC34)
Comments	Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists. Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Disease	Hepatocellular carcinoma of the mouse (NCIt: C38756)
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C3H/HeN.
Hierarchy	Parent: CVCL_DC33 (MLE/BV)
Category	Cancer cell line
Publications	PubMed=8812265; DOI=10.1006/faat.1996.0056 Patricia M. Garrison, Kathryn Tullis, Jac M.M.J.G. Aarts, Abraham Brouwer, John P. Giesy, Michael S. Denison; Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30:194-203(1996) Patent=US5854010 Michael S. Denison, Abraham Brouwer, George C. Clark; Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor. Patent number US5854010, 29-Dec-1998
Encyclopedic resources	Wikidata; Q54905971
Entry history
Entry creation	13-Jul-2016
Last entry update	14-Aug-2025
Version number	8