Cellosaurus cell line G16L1.1c8 (CVCL

Cellosaurus G16L1.1c8 (CVCL_DC17)

Cross-references
Cell line name	G16L1.1c8
Accession	CVCL_DC17
Resource Identification Initiative	To cite this cell line use: G16L1.1c8 (RRID:CVCL_DC17)
Comments	Biotechnology: Cell line developed for CALUX (Chemically Activated LUciferase eXpression) bioassay. CALUX is used for rapid screening of samples for the presence of dioxin/TCDD-like compounds and AhR agonists/antagonists. Characteristics: Acts through the activation of a luciferase reporter gene under the control of dioxin-response elements (DREs). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase. Transformant: ChEBI; CHEBI_50102; N-methyl-N-nitrosourea (NMU). Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Disease	Guinea pig colon adenocarcinoma (NCIt: C134563)
Species of origin	Cavia porcellus (Guinea pig) (NCBI Taxonomy: 10141)
Hierarchy	Parent: CVCL_3463 (GPC-16)
Sex of cell	Female
Age at sampling	Adult
Category	Cancer cell line
Web pages	Provider; XDSI; -; http://www.dioxins.com/products/
Publications	PubMed=8812265; DOI=10.1006/faat.1996.0056 Patricia M. Garrison, Kathryn Tullis, Jac M.M.J.G. Aarts, Abraham Brouwer, John P. Giesy, Michael S. Denison; Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30:194-203(1996) Patent=US5854010 Michael S. Denison, Abraham Brouwer, George C. Clark; Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefor. Patent number US5854010, 29-Dec-1998 PubMed=18969542; DOI=10.1016/j.talanta.2004.05.032 Michael S. Denison, Bin Zhao, David S. Baston, George C. Clark, Hiroshi Murata, Dalho Han; Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta 63:1123-1133(2004) PubMed=21394221; DOI=10.1007/s11426-010-0142-8; PMCID=PMC3049243 Bin Zhao, David S. Baston, Elaine Khan, Claudio Sorrentino, Michael S. Denison; Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci. China Chem. 53:1010-1016(2010) PubMed=26366531; DOI=10.1021/acs.est.5b02906; PMCID=PMC4772899 Jennifer C. Brennan, Guo-Chun He, Tomoaki Tsutsumi, Jing Zhao, Edward Wirth, Michael H. Fulton, Michael S. Denison; Development of species-specific Ah receptor-responsive third generation CALUX cell lines with enhanced responsiveness and improved detection limits. Environ. Sci. Technol. 49:11903-11912(2015)
Encyclopedic resources	Wikidata; Q54835369
Entry history
Entry creation	13-Jul-2016
Last entry update	14-Aug-2025
Version number	13