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Cellosaurus (CVCL_D8FI)

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Comments Population: Japanese.
Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter (InvivoGen=thpx-dmyd).
Knockout cell: Method=Not specified; HGNC; HGNC:7562; MYD88.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP.
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X582 (THP1-XBlue)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages Provider; InvivoGen; thpx-dmyd; https://web.archive.org/web/20170705151443/http://www.invivogen.com/thp1-xblue-defmyd-cell
Publications


Martina I. Reinhold, Jennifer M. Green, Frederik P. Lindberg, Michel Ticchioni, Eric J. Brown;
Cell spreading distinguishes the mechanism of augmentation of T cell activation by integrin-associated protein/CD47 and CD28.
Int. Immunol. 11:707-718(1999)

Cross-references
Encyclopedic resources Wikidata; Q54972377
Entry history
Entry creation05-Sep-2014
Last entry update10-Apr-2025
Version number19