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Cellosaurus NZM042 (CVCL_D833)

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Cell line name NZM042
Synonyms NZM42
Accession CVCL_D833
Resource Identification Initiative To cite this cell line use: NZM042 (RRID:CVCL_D833)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 70-80 hours (CBA=CBA-1391).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Not specified.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=32567790; CBA=CBA-1391).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
HLA typing Source: PubMed=32567790
Class I
HLA-AA*03:01,11:01
HLA-BB*07:02,45:01
HLA-CC*06:02,07:02
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S423 ! NZM048
Sex of cell Male
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1391; PubMed=32567790

Markers:
AmelogeninX,Y
CSF1PO9,12
D2S133817,20
D3S135816,17
D5S81812,13
D7S8208,10
D8S117914
D13S3178,11
D16S5399,11
D18S5114,16
D19S43315
D21S1129,32.2
FGA19,20
Penta D13,15
Penta E15,18
TH019,9.3
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=20041153; DOI=10.1371/journal.pone.0008461; PMCID=PMC2794539
Aaron R. Jeffs, Amy C. Glover, Lynn J. Slobbe, Li Wang, Shu-Jie He, Jody A. Hazlett, Anshul Awasthi, Adele G. Woolley, Elaine S. Marshall, Wayne R. Joseph, Cristin Gregor Print ...Show all 13 authors... , Bruce Charles Baguley, Michael R. Eccles; Show fewer authors
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:e8461.1-e8461.11(2009)

PubMed=22475322; DOI=10.1186/1471-2407-12-141; PMCID=PMC3352269
Ji Eun Kim, Clare J. Stones, Wayne R. Joseph, Euphemia Yee Leung, Graeme John Finlay, Andrew N. Shelling, Wayne A. Phillips, Peter R. Shepherd, Bruce Charles Baguley;
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC Cancer 12:141.1-141.10(2012)

PubMed=32567790; DOI=10.1111/pcmr.12908; PMCID=PMC7818249
Khanh B. Tran, Gregory Gimenez, Peter Tsai, Sharada Kolekar, Euan J. Rodger, Aniruddha Chatterjee, Anower Jabed, Jen-Hsing Shih, Wayne R. Joseph, Elaine S. Marshall, Qian Wang ...Show all 15 authors... , Cristin Gregor Print, Michael R. Eccles, Bruce Charles Baguley, Peter R. Shepherd; Show fewer authors
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1391
Cell line databases/resources cancercelllines; CVCL_D833
DepMap; ACH-001986
Biological sample resources BioSample; SAMN07624447
BioSample; SAMN14558339
Encyclopedic resources Wikidata; Q54931576
Polymorphism and mutation databases Cosmic; 1660298
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number21