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Cellosaurus NZM004 (CVCL_D831)

[Text version]
Cell line name NZM004
Synonyms NZM04; NZM4
Accession CVCL_D831
Resource Identification Initiative To cite this cell line use: NZM004 (RRID:CVCL_D831)
Comments Doubling time: 29.8 hours (CelloPub=CLPUB00227); 48 hours (CBA=CBA-1390).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23658559; PubMed=32567790).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
  • Mutation; HGNC; 11998; TP53; Simple; p.Ser241Pro (c.721T>C); ClinVar=VCV000376664; Zygosity=Unspecified (PubMed=11216673; PubMed=21912889).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1390; PubMed=32567790

Markers:
AmelogeninX
CSF1PO10
D2S133817,19
D3S135815,18
D5S8189
D7S8208,9
D8S117910,13
D13S31711,13
D16S53911,12
D18S5115 (CBA=CBA-1390)
15,20 (PubMed=32567790)
D19S43312,15
D21S1129,30
FGA23,24
TH018,9.3
TPOX8,11
vWA15

Run an STR similarity search on this cell line
Publications

PubMed=7999427; DOI=10.1016/0959-8049(94)90188-0
Marshall E.S., Matthews J.H.L., Shaw J.H.F., Nixon J., Tumewu P., Finlay G.J., Holdaway K.M., Baguley B.C.
Radiosensitivity of new and established human melanoma cell lines: comparison of [3H]thymidine incorporation and soft agar clonogenic assays.
Eur. J. Cancer 30:1370-1376(1994)

PubMed=11216673; DOI=10.3727/096504001108747620
Parmar J., Marshall E.S., Charters G.A., Holdaway K.M., Shelling A.N., Baguley B.C.
Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines.
Oncol. Res. 12:149-155(2000)

PubMed=20041153; DOI=10.1371/journal.pone.0008461
Jeffs A.R., Glover A.C., Slobbe L.J., Wang L., He S.-J., Hazlett J.A., Awasthi A., Woolley A.G., Marshall E.S., Joseph W.R., Print C.G., Baguley B.C., Eccles M.R.
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:E8461-E8461(2009)

CLPUB00227
Daukste L.
Mathematical modelling of cancer cell population dynamics.
Thesis PhD (2012), University of Canterbury, New Zealand

PubMed=21912889; DOI=10.1007/s10637-011-9744-z
Sutherland H.S., Hwang I.Y., Marshall E.S., Lindsay B.S., Denny W.A., Gilchrist C., Joseph W.R., Greenhalgh D., Richardson E., Kestell P., Ding A., Baguley B.C.
Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.
Invest. New Drugs 30:2035-2045(2012)

PubMed=23658559; DOI=10.3389/fgene.2013.00066
Stones C.J., Kim J.E., Joseph W.R., Leung E.Y., Marshall E.S., Finlay G.J., Shelling A.N., Baguley B.C.
Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors.
Front. Genet. 4:66.1-66.6(2013)

PubMed=23755070; DOI=10.3389/fgene.2013.00097
Kim J.E., Leung E.Y., Baguley B.C., Finlay G.J.
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.
Front. Genet. 4:97.1-97.8(2013)

PubMed=24455489; DOI=10.3389/fonc.2013.00333
D'mello S.A.N., Flanagan J.U., Green T.N., Leung E.Y., Askarian-Amiri M.E., Joseph W.R., McCrystal M.R., Isaacs R.J., Shaw J.H.F., Furneaux C.E., During M.J., Finlay G.J., Baguley B.C., Kalev-Zylinska M.L.
Evidence that GRIN2A mutations in melanoma correlate with decreased survival.
Front. Oncol. 3:333.1-333.9(2014)

PubMed=32567790; DOI=10.1111/pcmr.12908
Tran K.B., Gimenez G., Tsai P., Kolekar S., Rodger E.J., Chatterjee A., Jabed A., Shih J.-H., Joseph W.R., Marshall E.S., Wang Q., Print C.G., Eccles M.R., Baguley B.C., Shepherd P.R.
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1390
Cell line databases/resources cancercelllines; CVCL_D831
Biological sample resources BioSample; SAMN07624445
BioSample; SAMN14558315
Encyclopedic resources Wikidata; Q54931572
Polymorphism and mutation databases Cosmic; 2007645
Cosmic; 2141925
IARC_TP53; 14964
Entry history
Entry creation22-Oct-2012
Last entry update02-May-2024
Version number20