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Cellosaurus NZM012 (CVCL_D818)

[Text version]
Cell line name NZM012
Synonyms NZM12
Accession CVCL_D818
Resource Identification Initiative To cite this cell line use: NZM012 (RRID:CVCL_D818)
Comments Doubling time: 25.9 hours (CelloPub=CLPUB00227); 40-42 hours (CBA=CBA-1383).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Small intestine; UBERON=UBERON_0002108.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23755070; PubMed=32567790).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=32567790).
HLA typing Source: PubMed=32567790
Class I
HLA-AA*02:01,32:01
HLA-BB*44:02,44:02
HLA-CC*01:02,05:01
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): CBA=CBA-1383; PubMed=32567790

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133823,25
D3S135815,16
D5S8189,12
D7S82010,12
D8S117911,14
D13S31710,11
D16S53911,12
D18S5112
D19S43312,13
D21S1128,29
FGA20,23
Penta D9,13
Penta E5,16
TH017
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=11216673; DOI=10.3727/096504001108747620
Jayamala Parmar, Elaine S. Marshall, Geoffrey A. Charters, Karen M. Holdaway, Andrew N. Shelling, Bruce Charles Baguley;
Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines.
Oncol. Res. 12:149-155(2000)

PubMed=20041153; DOI=10.1371/journal.pone.0008461; PMCID=PMC2794539
Aaron R. Jeffs, Amy C. Glover, Lynn J. Slobbe, Li Wang, Shu-Jie He, Jody A. Hazlett, Anshul Awasthi, Adele G. Woolley, Elaine S. Marshall, Wayne R. Joseph, Cristin Gregor Print ...Show all 13 authors... , Bruce Charles Baguley, Michael R. Eccles; Show fewer authors
A gene expression signature of invasive potential in metastatic melanoma cells.
PLoS ONE 4:e8461.1-e8461.11(2009)

CLPUB00227
Liene Daukste;
Mathematical modelling of cancer cell population dynamics.
Thesis PhD (2012); University of Canterbury; Christchurch; New Zealand

PubMed=22475322; DOI=10.1186/1471-2407-12-141; PMCID=PMC3352269
Ji Eun Kim, Clare J. Stones, Wayne R. Joseph, Euphemia Yee Leung, Graeme John Finlay, Andrew N. Shelling, Wayne A. Phillips, Peter R. Shepherd, Bruce Charles Baguley;
Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines.
BMC Cancer 12:141.1-141.10(2012)

PubMed=23755070; DOI=10.3389/fgene.2013.00097; PMCID=PMC3668138
Ji Eun Kim, Euphemia Yee Leung, Bruce Charles Baguley, Graeme John Finlay;
Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.
Front. Genet. 4:97.1-97.8(2013)

PubMed=32567790; DOI=10.1111/pcmr.12908; PMCID=PMC7818249
Khanh B. Tran, Gregory Gimenez, Peter Tsai, Sharada Kolekar, Euan J. Rodger, Aniruddha Chatterjee, Anower Jabed, Jen-Hsing Shih, Wayne R. Joseph, Elaine S. Marshall, Qian Wang ...Show all 15 authors... , Cristin Gregor Print, Michael R. Eccles, Bruce Charles Baguley, Peter R. Shepherd; Show fewer authors
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: a valuable model for studying the impact of genetic diversity in melanoma.
Pigment Cell Melanoma Res. 34:136-143(2021)

Cross-references
Cell line collections (Providers) CBA; CBA-1383
Cell line databases/resources cancercelllines; CVCL_D818
Biological sample resources BioSample; SAMN07624441
BioSample; SAMN14558321
Encyclopedic resources Wikidata; Q54931528
Polymorphism and mutation databases Cosmic; 1660300
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number22