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Cellosaurus HeLa M TBK1-KO (CVCL_D7ES)

[Text version]
Cell line name HeLa M TBK1-KO
Accession CVCL_D7ES
Resource Identification Initiative To cite this cell line use: HeLa M TBK1-KO (RRID:CVCL_D7ES)
Comments Population: African American.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11584; TBK1.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_R965 (HeLa M)
Children:
CVCL_D7EU (HeLa M TBK1-KO + RAB7-KO)CVCL_D7EV (HeLa M TBK1-KO + TBK1-E696K-GFP)CVCL_D7EY (HeLa M TBK1-KO + TBK1-GFP)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
Publications

PubMed=39103493; DOI=10.1038/s44318-024-00180-8; PMCID=PMC11405869
Gabriel Talaia, Amanda Bentley-DeSousa, Shawn M. Ferguson;
Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition.
EMBO J. 43:3948-3967(2024)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number4