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Cellosaurus U2OS-GFP-STAT1/CSF-1R (CVCL_D7E2)

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Cell line name U2OS-GFP-STAT1/CSF-1R
Accession CVCL_D7E2
Resource Identification Initiative To cite this cell line use: U2OS-GFP-STAT1/CSF-1R (RRID:CVCL_D7E2)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China General Microbiological Culture Collection Center; CGMCC No.4688.
Population: Caucasian.
Characteristics: Expresses both GFP-STAT1 and CSF1R (Patent=US9683988).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2433; CSF1R.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11362; STAT1.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D7E1 (U2OS-GFP-STAT1)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

Patent=US9683988
Li-Li Wang, Sheng-Qian Yang, Long Long, Jun-Hai Xiao, Song Li;
Cell model and method for screening c-Fms kinase inhibitors.
Patent number US9683988, 20-Jun-2017

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number4