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Cellosaurus MOLM-13-RES-AC (CVCL_D780)

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Cell line name MOLM-13-RES-AC
Accession CVCL_D780
Resource Identification Initiative To cite this cell line use: MOLM-13-RES-AC (RRID:CVCL_D780)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_90217; Quizartinib (AC220).
Selected for resistance to: ChEBI; CHEBI_90237; Tandutinib (MLN518; CT53518).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Unexplicit; Internal tandem duplication (FLT3-ITD); ClinVar=VCV000016270; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Myelodysplastic syndrome (NCIt: C3247)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D779 (MOLM-13-RES)
Sex of cell Male
Age at sampling 20Y
Category Cancer cell line
Publications

PubMed=22354205; DOI=10.1038/leu.2012.52; PMCID=PMC3523391
Andrew S. Moore, Amir Faisal, David Gonzalez de Castro, Vassilios Bavetsias, Chong-Bo Sun, Butrus Atrash, Melanie Valenti, Alexis Katherine De Haven Brandon, Sian Avery, Debbie Mair, Fabio Mirabella ...Show all 18 authors... , John Swansbury, Andrew D.J. Pearson, Paul Workman, Julian Blagg, Florence I. Raynaud, Suzanne A. Eccles, Spiros Linardopoulos; Show fewer authors
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns.
Leukemia 26:1462-1470(2012)

Cross-references
Encyclopedic resources Wikidata; Q54906322
Polymorphism and mutation databases Cosmic; 1741691
Entry history
Entry creation22-Oct-2012
Last entry update27-Nov-2025
Version number18