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Cellosaurus 11-18-GEF20-1 (CVCL_D777)

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Cell line name 11-18-GEF20-1
Synonyms 11-18/GEF20-1
Accession CVCL_D777
Resource Identification Initiative To cite this cell line use: 11-18-GEF20-1 (RRID:CVCL_D777)
Comments Population: Japanese and Micro.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6659 (11-18)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22815900; DOI=10.1371/journal.pone.0041017; PMCID=PMC3398867
Keisuke Tabara, Rina Kanda, Kahori Sonoda, Takuya Kubo, Yuichi Murakami, Akihiko Kawahara, Koichi Azuma, Hideyuki Abe, Masayoshi Kage, Aki Yoshinaga, Tomoko Tahira ...Show all 17 authors... , Kenshi Hayashi, Tokuzo Arao, Kazuto Nishio, Rafael Rosell, Michihiko Kuwano, Mayumi Ono; Show fewer authors
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:e41017.1-e41017.16(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D777
Encyclopedic resources Wikidata; Q54554911
Polymorphism and mutation databases Cosmic; 1731376
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number16