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Cellosaurus KMS-11R (CVCL_D705)

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Cell line name KMS-11R
Accession CVCL_D705
Resource Identification Initiative To cite this cell line use: KMS-11R (RRID:CVCL_D705)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Selected for resistance to: AZ12908010 (AZ8010).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5723; IGKJ5 + HGNC; HGNC:5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=22869148; DOI=10.1038/onc.2012.319
Victoria Chell, Kathryn Balmanno, Annette S. Little, Michael Wilson, Simon Andrews, Laura Blockley, Mark Hampson, Paul R. Gavine, Simon J. Cook;
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.
Oncogene 32:3059-3070(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D705
Encyclopedic resources Wikidata; Q54900167
Polymorphism and mutation databases Cosmic; 1740214
Entry history
Entry creation22-Oct-2012
Last entry update14-Aug-2025
Version number18