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Cellosaurus KMS-11R (CVCL_D705)

[Text version]
Cell line name KMS-11R
Accession CVCL_D705
Resource Identification Initiative To cite this cell line use: KMS-11R (RRID:CVCL_D705)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Selected for resistance to: AZ12908010 (AZ8010).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=22869148; DOI=10.1038/onc.2012.319
Chell V., Balmanno K., Little A.S., Wilson M., Andrews S., Blockley L., Hampson M., Gavine P.R., Cook S.J.
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance.
Oncogene 32:3059-3070(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D705
Encyclopedic resources Wikidata; Q54900167
Polymorphism and mutation databases Cosmic; 1740214
Entry history
Entry creation22-Oct-2012
Last entry update05-Oct-2023
Version number15