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Cellosaurus HCC38rDOX40 (CVCL_D6VL)

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Cell line name HCC38rDOX40
Synonyms HCC38 rDoxorubicin40
Accession CVCL_D6VL
Resource Identification Initiative To cite this cell line use: HCC38rDOX40 (RRID:CVCL_D6VL)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Leu (c.818G>T); ClinVar=VCV000376655; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1267 (HCC38)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=40300663; DOI=10.1016/j.canlet.2025.217754
Helen E. Grimsley, Magdalena Antczak, Ian G. Reddin, Nicole Weiler, Katie-May McLaughlin, Florian Rothweiler, Johannes Haas, Andrea Nist, Marco Mernberger, Thorsten Stiewe, Tim R. Fenton ...Show all 19 authors... , Daniel Speidel, Catherine Harper-Wynne, Karina Cox, Dirk Heckl, Jindrich Cinatl Jr., Mark N. Wass, Michelle D. Garrett, Martin Michaelis; Show fewer authors
Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers.
Cancer Lett. 624:217754.1-217754.14(2025)

Entry history
Entry creation10-Sep-2024
Last entry update14-Aug-2025
Version number3