| Cell line name |
TC-71 EHD1 KO |
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| Synonyms |
EHD1-KO TC71 |
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| Accession |
CVCL_D6TX |
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| Resource Identification Initiative |
To cite this cell line use: TC-71 EHD1 KO (RRID:CVCL_D6TX) |
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| Comments |
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3242; EHD1.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976. |
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| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_2213 (TC-71) |
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| Sex of cell |
Male |
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| Age at sampling |
22Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=37474760; DOI=10.1038/s42003-023-05125-1; PMCID=PMC10359273
Sukanya Chakraborty, Aaqib M. Bhat, Insha Mushtaq, Hai-Tao Luan, Achyuth Kalluchi, Sameer Mirza, Matthew D. Storck, Nagendra Chaturvedi, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Isidro Machado ...Show all 19 authors... , Katia Scotlandi, Jane L. Meza, Gargi Ghosal, Donald W. Coulter, Michael Jordan Rowley, Vimla Band, Bhopal C. Mohapatra, Hamid Band; Show fewer authors
EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis.
Commun. Biol. 6:758.1-758.21(2023) |
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| Entry history |
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| Entry creation | 10-Sep-2024 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 3 |
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