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Cellosaurus WTSIi018-B-19 (CVCL_D6RH)

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Cell line name WTSIi018-B-19
Synonyms DU325; IUFi019-A-19
Accession CVCL_D6RH
Resource Identification Initiative To cite this cell line use: WTSIi018-B-19 (RRID:CVCL_D6RH)
Comments From: Leibniz Research Institute for Environmental Medicine; Dusseldorf; Germany.
Population: Caucasian; British.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:132; ACTB (Note=1 of 2 alleles).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:18037; ARID2; Simple_corrected; p.Pro197Hisfs*12 (c.590_608delCTAAAATCATCACTTTACT); Zygosity=Heterozygous; Note=By CRISPR/Cas9 (from parent cell line).
  • Mutation; HGNC; HGNC:2201; COL3A1; Simple; c.3526-1G>A; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:2201; COL3A1; Simple; p.Gly1176Ser (c.3526G>A); Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B5P3 (KOLF2.1J)
Sex of cell Male
Age at sampling 55-59Y
Category Induced pluripotent stem cell
STR profile Source(s): PubMed=38518401

Markers:
AmelogeninX,Y
CSF1PO11,12
D1S165614,18.3
D2S133817,19
D3S135816
D5S81812,13
D6S104312,20
D7S8209,11
D8S117911,14
D12S39118,22
D13S3179,10
D16S5399,13
D18S5112,17
D19S43314,15
D21S1131,32.2
FGA21
Penta D12,15
Penta E10,12
TH016,9.3
TPOX8,11
vWA14

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Publications

PubMed=38518401; DOI=10.1016/j.scr.2024.103395
Stephanie Binder, Haribaskar Ramachandran, Denise Haslinger, Barbara Hildebrandt, Jochen Dobner, Thomas Haarmann-Stemmann, Andreas Geburtig Chiocchetti, Andrea Rossi;
CRISPR/Cas9-mediated editing of ACTB in induced pluripotent stem cells: a model for investigating human ACTB loss-of-function and genetic adaptive responses.
Stem Cell Res. 77:103395-103395(2024)

Cross-references
Cell line databases/resources hPSCreg; WTSIi018-B-19
Biological sample resources BioSamples; SAMEA115295914
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2