Cellosaurus cell line HyCyte HCCLM3 KO-hUSP22 (CVCL

Cross-references
Cell line name	HyCyte HCCLM3 KO-hUSP22
Synonyms	hUSP22 knockout HCCLM3
Accession	CVCL_D6B8
Resource Identification Initiative	To cite this cell line use: HyCyte HCCLM3 KO-hUSP22 (RRID:CVCL_D6B8)
Comments	Population: Chinese. Doubling time: 36-48 hours (Hysigen=CGKO-M2426). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:12621; USP22. Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Sequence variations	Mutation; HGNC; HGNC:14310; BRD7; Simple; p.Glu277Glyfs18 (c.830_831delAG); Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:23177; KEAP1; Simple; p.Pro445Glnfs13 (c.1334delC); Zygosity=Unspecified (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu51Ter (c.151G>T); ClinVar=VCV000568781; Zygosity=Unspecified (from parent cell line).
Disease	Adult hepatocellular carcinoma (NCIt: C7956) Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_6832 (HCCLM3)
Sex of cell	Male
Age at sampling	39Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M2426
Encyclopedic resources	Wikidata; Q127382008
Entry history
Entry creation	02-May-2024
Last entry update	27-Nov-2025
Version number	4